Title

Comment on “Photodegradation of sulfathiazole under simulated sunlight: Kinetics, photo-induced structural rearrangement, and antimicrobial activities of photoproducts”

Department/School

Chemistry

Date

3-15-2018

Document Type

Article

Keywords

analysis, antibiotic, antimicrobial activity, antimicrobial susceptibility, green technology, sulfadiazine, sulfathiazole, sulfonamide, sulfonamides

DOI

https://doi.org/10.1016/j.watres.2017.12.041

Abstract

Recent efforts have employed antimicrobial susceptibility assays to describe the residual antimicrobial activity of antibiotics and their transformation products in a variety of environmental processes. Some authors have evaluated the results of these assays using the minimum inhibitory concentration (MIC); however, this approach has fundamental weaknesses. To highlight best practices, this comment describes the advantages of using dose-response curves to calculate the half maximal inhibitory concentration (IC50) and the potential impacts of growth media on the antimicrobial activity of sulfonamide antibiotics. •Disadvantages of MIC-based analysis of residual antimicrobial activity.•Comparison of IC50 values is best practice for antimicrobial activity measurement.•Growth media may interfere with antimicrobial activity of sulfonamides.

Published in

Water Research

Citation/Other Information

Hain, E., K.H. Wammer, L. Blaney. 2018. “Comment on Photodegradation under simulated sunlight: Kinetics, photo-induced structural rearrangement, and antimicrobial activities of photoproducts by Niu et al. [Water Research 124 2017 576-583]. Water Research, 131:205-207. DOI: 10.1016/j.watres.2017.12.041

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