Title
Comment on “Photodegradation of sulfathiazole under simulated sunlight: Kinetics, photo-induced structural rearrangement, and antimicrobial activities of photoproducts”
Department/School
Chemistry
Date
3-15-2018
Document Type
Article
Keywords
analysis, antibiotic, antimicrobial activity, antimicrobial susceptibility, green technology, sulfadiazine, sulfathiazole, sulfonamide, sulfonamides
DOI
https://doi.org/10.1016/j.watres.2017.12.041
Abstract
Recent efforts have employed antimicrobial susceptibility assays to describe the residual antimicrobial activity of antibiotics and their transformation products in a variety of environmental processes. Some authors have evaluated the results of these assays using the minimum inhibitory concentration (MIC); however, this approach has fundamental weaknesses. To highlight best practices, this comment describes the advantages of using dose-response curves to calculate the half maximal inhibitory concentration (IC50) and the potential impacts of growth media on the antimicrobial activity of sulfonamide antibiotics. •Disadvantages of MIC-based analysis of residual antimicrobial activity.•Comparison of IC50 values is best practice for antimicrobial activity measurement.•Growth media may interfere with antimicrobial activity of sulfonamides.
Published in
Water Research
Citation/Other Information
Hain, E., K.H. Wammer, L. Blaney. 2018. “Comment on Photodegradation under simulated sunlight: Kinetics, photo-induced structural rearrangement, and antimicrobial activities of photoproducts by Niu et al. [Water Research 124 2017 576-583]. Water Research, 131:205-207. DOI: 10.1016/j.watres.2017.12.041