Title

Identifying knots in proteins

Department/School

Mathematics

Date

3-21-2013

Document Type

Article

Keywords

knots, proteins, polypeptide chains

Abstract

Polypeptide chains form open knots in many proteins. How these knotted proteins fold and finding the evolutionary advantage provided by these knots are among some of the key questions currently being studied in the protein folding field. The detection and identification of protein knots are substantial challenges. Different methods and many variations of them have been employed, but they can give different results for the same protein. In the present article, we review the various knot identification algorithms and compare their relative strengths when applied to the study of knots in proteins. We show that the statistical approach based on the uniform closure method is advantageous in comparison with other methods used to characterize protein knots.

Published in

Biochemical Society Transactions

Citation/Other Information

Millett, K. C., Rawdon, E. J., Stasiak, A., & Sułkowska, J. I. (2013). Identifying knots in proteins. Biochemical Society Transactions, 41(2), 533–537. https://doi.org/10.1042/BST20120339

Share

COinS